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Publications, Patents, Book Chapters
Currently I am working towards optimization of anticancer activity of recently discovered tubulin interactive compound Noscapine and its derivatives.
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My current project involves the design and synthesis of novel analogs of Noscapine. Moreover, I am also preparing conjugates of known cancer drugs like Docetaxel and Doxorubicin and potent Noscapine analogs with Peptides and Biomolecules which are over expressed in different kind of tumor cells using Cleavable Linkers. Apart from this I have also conjugated a derivative of Noscapine with NIR dyes which have selective binding affinity with tumor cells. The work from the current project has resulted in the preparation of a number of manuscripts and patent application.
I have expertise in the design and synthesis of Nucleosides (natural, unnatural and fluorescent) Nucleotides, Carbohydrates, Heterocycles and Natural products. I use various spectroscopic techniques (NMR, MS, IR, UV etc.) to characterize the novel molecules.
In my Doctoral Research, most of the work was related to synthesis of Glycoconjugates, C-Nucleosides and Unnatural nucleosides. I also have hands-on experience in combinatorial synthesis and automated small molecule synthesizer.
In my research career till date I have published 20 papers in international journals and applied for 5 Indian and 1 US patent (in process).
My Research Interests include, Cancer Biology, Drug Design, Targeted Drug Delivery (Receptor and Nanoparticle assisted) and Biological Imaging. I do also have high enthusiasm to design and develop novel small molecules having Carbohydrate, Nucleoside or Natural product skeleton for therapeutic purpose.
Incoming search terms:
- rc mishra reaserch
7 comments
Arvind Mishra
April 16, 2011 at 7:20 am (UTC 0) Link to this comment
Your current work on cancer biology looks very promising in context to alleviate human sufferings from the dreaded disease.Please keep it up!
Nige R Nigga
October 22, 2011 at 8:10 pm (UTC 0) Link to this comment
great research!
Nige R Nigga
October 24, 2011 at 5:13 pm (UTC 0) Link to this comment
Why did you delete my comment?
I really think this is great research!
Tumor rupture
January 30, 2012 at 4:53 pm (UTC 0) Link to this comment
Cancer found in the cells with the busts is breast cancers. So thousands of breast tissue which is developing in the abnormal along with out of control means can be a dangerous cancer.
Diq N Mahazz
February 21, 2012 at 5:18 pm (UTC 0) Link to this comment
You must contiune research such as this Dr, you help so many people with these research!
Schmelly Cawk
April 24, 2012 at 11:12 pm (UTC 0) Link to this comment
My great friend told me about said reasearch, and i agree with Tumor!
keep up this great Reaserch!
AzzWhole Breeth
May 17, 2012 at 7:10 pm (UTC 0) Link to this comment
Wow!